Ablative Solutions

Ablative Solutions is a clinical-stage medical device start-up that is pioneering the novel approach of Transcatheter Perivascular Alcohol Denervation for the treatment of hypertension. Hypertension, or high blood pressure, is a modern day epidemic, affecting more than one billion people worldwide and an estimated 67 million in the United States alone. Often described as the silent killer, hypertension is strongly associated with heart disease and stroke. Increased sympathetic nerve activity plays a key role in the pathophysiology of hypertension. By disrupting, or denervating these sympathetic nerves, clinicians can alter this overactive signaling process and reduce patients blood pressure. First-generation approaches using radio-frequency energy produced encouraging results, but these systems are challenged by their inability to reach the target nerves, which lie outside of the treatment range of the energy employed. Ablative Solutions has developed the Peregrine...