ARCHI-CARD (I2MC-UMR1297)

The physiologic response of an organ basically relies on a complex interplay between the different cell types structuring its tissue. At the cellular level, the response arises from the plasma membrane through different receptors, channels, pumps... that integrate and process the extracellular stimuli (chemical, mechanical). Alteration of the plasma membrane response is the hallmark of a number of pathological conditions. Now, how the plasma membrane and the overall cell architecture behave in such pathologies and what is the impact on the surface organization and functions of the proteins inserted in the plasma membrane still remain poorly understood. This is however of major interest in pharmacological medicine since most marketed drugs target these plasma membrane proteins. In this context, the research program of our team focuses on understanding the relationship between the architecture of cardiac tissue (more precisely of the cardiac contractile cells) on the function and pha...