Presage Biosciences, Inc

What if you could test the efficacy of multiple new cancer drugs in a patient without harmful side effects? We asked this question when we started Presage to address a fundamental issue that hampers development of new cancer drugs. The issue as we see it is that new drugs are tested in laboratory models of cancer that simply do not accurately represent the complexity of the human tumor microenvironment and therefore do not reliably predict patient benefit in the clinic. As a result, drugs that exhibit outstanding performance in preclinical models of cancer more often than not, fail to provide benefit to patients when these same agents are tested in clinical trials. Its hard to deny this issue. The composite success rate for cancer drug candidates entering trials is a dismal 8%. This overwhelming percentage of clinical failures comes at tremendous cost to drug developers ($100s of millions to billions), and most importantly to patients in need of new therapy options. We can do bette...