The SGC Frankfurt

The Structural Genomics Consortium at the Goethe University Frankfurt (SGC Frankfurt) is focused on the development and rational design of selective inhibitors (chemical probes) targeting key signaling molecules and their use for the validation of new targets. The research team focusses on the following key areas: *Kinases: Strategies for the development of highly specific inhibitors will be focused on a) allosteric inhibitors and inhibitors targeting unique active site pockets. This approach allows us to interrogate catalytic as well as scaffolding functions of kinases exploring also catalytically inactive or weakly active pseudokinases as drug targets; b) We are also developing covalent kinase inhibitors by targeting cysteines in the proximity of the ATP binding pocket using electrophilic groups and c) we are exploring improved shape compatibility using macrocycles to generate novel and more specific kinase inhibitors targeting the active (type I) and inactive states (type II). ...